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Does Semaglutide Make You Tired? Here’s Why and How to Fix It

Semaglutide has become a popular and effective weight loss medication, but like any treatment, it can come with some side effects. One of the more commonly reported ones is fatigue or feeling unusually tired. Does semaglutide make you tired? If so, you’re not alone. Many people on semaglutide experience this side effect, especially in the early stages of treatment. Let’s explore why semaglutide might cause fatigue, and more importantly, how to fix it so you can stay on track with your weight loss goals.

Why Does Semaglutide Make You Tired?

While semaglutide is primarily used to manage blood sugar levels and promote weight loss, the way it interacts with your body can sometimes lead to feelings of tiredness. There are a few reasons why you might feel more fatigued while on this medication:

1. Changes in Blood Sugar Levels

Semaglutide works by regulating your body’s insulin and glucose levels. For those with diabetes, it helps lower blood sugar, and for individuals focused on weight loss, it can suppress appetite. While these effects are beneficial for health and weight management, fluctuations in blood sugar can sometimes lead to fatigue, especially if your body is still adjusting to the medication.

2. Reduced Calorie Intake

Because semaglutide helps control appetite, you may find yourself eating less. While this is great for weight loss, a significant reduction in calorie intake can sometimes leave you feeling tired. Your body is adjusting to fewer calories, which can result in lower energy levels as it adapts.

3. Dehydration

Semaglutide can sometimes cause mild dehydration, particularly if you’re experiencing other side effects like nausea. When your body isn’t getting enough fluids, you’re more likely to feel fatigued. Staying properly hydrated is essential for maintaining energy levels.

4. Initial Adjustment Period

As with most medications, your body needs time to adjust to semaglutide. During the first few weeks, it’s not uncommon to experience a bit of fatigue as your body adapts to the changes in appetite regulation, blood sugar control, and hormone levels.

How to Fix Fatigue While Taking Semaglutide

If you’ve been feeling more tired than usual while taking semaglutide, don’t worry — there are several steps you can take to manage and reduce fatigue without compromising your weight loss progress.

1. Stay Hydrated

Dehydration is a common cause of fatigue, and it’s especially important to pay attention to your fluid intake while on semaglutide. Aim for at least 8 cups of water a day, or more if you're active. Staying hydrated not only helps fight fatigue but also keeps your body functioning optimally as it adjusts to the medication.

2. Balance Your Meals

While semaglutide may reduce your appetite, it’s crucial to ensure that the calories you do consume are nutrient-dense. Focus on balanced meals with plenty of lean protein, healthy fats, and complex carbohydrates to give your body sustained energy. Don’t skip meals, even if you’re not feeling particularly hungry, as this can lead to energy crashes.

Click here for our guide on how to balance your plate.

3. Get Enough Sleep

Fatigue can also stem from poor sleep quality. Make sure you’re getting 7-9 hours of sleep each night to allow your body to recover and recharge. A good night’s rest can significantly improve your energy levels during the day, helping you feel more refreshed while on semaglutide.

4. Ease Into Physical Activity

While regular exercise is key for both weight loss and overall health, it’s important to listen to your body. If you’re feeling especially tired, consider starting with lighter activities like walking, stretching, or yoga. As your body adjusts to semaglutide and your energy levels improve, you can gradually increase the intensity of your workouts.

5. Speak to Your Healthcare Provider

If your fatigue persists or becomes severe, it’s important to consult your healthcare provider. They may recommend adjusting your dosage or suggest other strategies to help mitigate tiredness. In some cases, other medications or health conditions could be contributing to your fatigue, and addressing those underlying factors can make a big difference.

How Brello Can Help You Manage Side Effects

At Brello, we understand that side effects like fatigue can be a challenge when starting a new weight loss treatment. We are here to guide you every step of the way, helping you manage any side effects while keeping you on track toward your weight loss goals.

Tailored Supplements for GLP-1 Users

In collaboration with Woven, we offer specialized supplements for GLP-1 users and help manage side effects like fatigue, stress, and more.

  • MentalMag Caps: Supports healthy brain function, cognitive health, and stress management. Magnesium is essential for overall health and is known to help with fatigue and mental clarity.*
  • MentalMag Powder: An advanced brain-boosting formula, designed to promote stress management and cognitive health, while providing optimal magnesium levels for GLP-1 patients experiencing fatigue.*
  • Omega Flow: Helps with circulation support and cognitive function. Omega-3 fatty acids promote brain health, which can be beneficial for those experiencing mental fog or fatigue while on semaglutide or tirzepatide.*
  • Vital-D Strength: Supports bone and immune health with a specialized formula containing Vitamin D. This can help address any deficiencies while keeping your body strong and energized.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

GLP-1 Medications That Work for You

Whether you’re on semaglutide or considering tirzepatide, Brello’s GLP-1 medications are designed to help you achieve your weight loss goals without compromising your overall well-being. We work closely with you to ensure the medication is effective and manageable, with as few side effects as possible.

Overcome Fatigue and Stay on Track

Feeling tired while taking semaglutide can be frustrating, but with the right strategies in place, you can overcome this side effect and continue your weight loss journey successfully. By staying hydrated, balancing your meals, getting enough sleep, and speaking to your healthcare provider when needed, you can manage fatigue and stay focused on your goals.

If you’re ready to take control of your health and manage side effects like fatigue with confidence, Brello is here to help. Click here to learn more and get started with our weight loss plans!

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References:

  1. https://www.fda.gov/news-events/press-announcements/fda-approves-new-medication-chronic-weight-management
  2. Azuri J, Hammerman A, Aboalhasan E, Sluckis B, Arbel R. Tirzepatide versus semaglutide for weight loss in patients with type 2 diabetes mellitus: A value for money analysis. Diabetes Obes Metab. 2023; 25(4): 961-964. doi:10.1111/dom.14940
  3. Aronne LJ, Sattar N, Horn DB, et al. Continued Treatment With Tirzepatide for Maintenance of Weight Reduction in Adults With Obesity: The SURMOUNT-4 Randomized Clinical Trial. JAMA. 2024;331(1):38–48. doi:10.1001/jama.2023.24945