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How Long Does It Take for GLP-1 Medications to Work?

When starting weight loss medications like semaglutide and tirzepatide, the burning question on everyone’s mind is: “How long will it take to see results?” After all, this is an exciting phase in your weight loss journey, where anticipation runs high as you look forward to the changes these treatments can bring.

Both semaglutide and tirzepatide are popular GLP-1 medications, each working in unique ways to help you achieve your health goals. Understanding the timeline for these medications can set realistic expectations and help maintain motivation throughout your journey.

Semaglutide: Timing and Expectations

Semaglutide is a GLP-1 receptor agonist that has shown significant results in both diabetes management and weight loss. Here’s what you can generally expect:

Initial Effects on Blood Sugar

Semaglutide begins influencing blood sugar levels within the first few weeks of treatment. You might notice changes in your blood sugar readings fairly quickly, which is encouraging for those also using semaglutide to manage diabetes.

Weight Loss Timeline

While initial effects on blood sugar are quick, weight loss usually takes longer to become noticeable. Most patients observe significant weight loss results within 8 to 12 weeks of consistent use. It’s important to maintain a consistent dosage and integrate lifestyle changes, such as diet and exercise, to see optimal results.

Long-term Effects

The journey doesn’t stop after a few months. The maximum impact of semaglutide, especially in terms of weight reduction, might take up to six months or more. A study published in The New England Journal of Medicine found that patients taking semaglutide experienced a mean weight loss of 14.9% at week 68. This extended timeline underscores the importance of persistence and adherence to your prescribed treatment plan.

Tirzepatide: Efficacy and Duration

Tirzepatide, which acts on both GLP-1 and GIP receptors, offers a dual approach to managing blood sugar and facilitating weight loss.

Initial Action

Tirzepatide starts to work within hours of injection, affecting insulin levels and blood sugar management. However, changes in blood glucose levels might not be noticeable to patients until after the first month.

Progressive Weight Loss

For weight management, visible weight loss generally begins to manifest after about 8 to 20 weeks of treatment. This window can vary widely depending on individual factors such as diet, exercise habits, and metabolic health.

Peak Benefits

The journey with tirzepatide is a marathon, not a sprint. Maximum benefits, particularly in terms of weight loss, may continue to develop over a year. A study published in Nature Medicine found that patients taking tirzepatide experienced a mean weight loss of 18.4% at week 72.

The study also found that patients taking tirzepatide who also completed intensive lifestyle intervention (reduced calorie diet, 150 minutes of physical activity per week, and counseling sessions with a dietitian) lost an average of 24.3% of their body weight, highlighting the compounding benefits a healthy lifestyle can have.

Factors Influencing Effectiveness

Both semaglutide and tirzepatide are potent medications, but their effectiveness can be influenced by several factors:

  • Overall Health: Pre-existing conditions and general health status can affect how your body responds to these medications.
  • Lifestyle: Diet and physical activity levels play significant roles in enhancing the effectiveness of GLP-1 medications.
  • Adherence to Medication: Consistency in taking your medication as prescribed is crucial for achieving the best results.

Brello: Your Partner in Weight Loss

At Brello, we understand that managing weight can be a complex and deeply personal journey. Whether you’re considering starting on semaglutide or tirzepatide, Brello is here to support you. We offer both medications to fit your unique needs and goals.

Weight loss is a journey that requires patience, support, and the right tools. With Brello, you’re not alone. We’re committed to providing you with the guidance and care needed to navigate this path successfully.

If you’re ready to take control of your health with the help of GLP-1 medications, click here to learn more and get started.

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References:

  1. https://www.fda.gov/news-events/press-announcements/fda-approves-new-medication-chronic-weight-management
  2. Azuri J, Hammerman A, Aboalhasan E, Sluckis B, Arbel R. Tirzepatide versus semaglutide for weight loss in patients with type 2 diabetes mellitus: A value for money analysis. Diabetes Obes Metab. 2023; 25(4): 961-964. doi:10.1111/dom.14940
  3. Aronne LJ, Sattar N, Horn DB, et al. Continued Treatment With Tirzepatide for Maintenance of Weight Reduction in Adults With Obesity: The SURMOUNT-4 Randomized Clinical Trial. JAMA. 2024;331(1):38–48. doi:10.1001/jama.2023.24945