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GLP-1s are medications used to treat conditions such as type 2 diabetes and obesity. They work by mimicking hormones in your body to help regulate blood sugar and support weight loss.
GLP-1s help curb food craving by suppressing appetite
GLP-1s improve insulin sensitivity and fat metabolism
GLP-1s slow digestion to make you feel full longer after meals
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GLP-1 is a peptide hormone that plays a crucial role in regulating blood sugar levels and metabolism in the body. It is produced by the cells in the lining of the small intestine and released in response to food intake, particularly in response to the presence of nutrients like glucose. GLP-1 has several important functions:
Insulin Release: One of the primary functions of GLP-1 is to stimulate the release of insulin from the pancreas. Insulin helps lower blood sugar levels by facilitating the uptake of glucose from the bloodstream into cells, where it can be used for energy or stored.
Inhibition of Glucagon Release: GLP-1 also suppresses the release of glucagon, another pancreatic hormone. Glucagon raises blood sugar levels by promoting the release of glucose from the liver. Inhibition of glucagon release by GLP-1 helps to prevent excessive glucose production.
Slowing Gastric Emptying: GLP-1 slows down the rate at which the stomach empties its contents into the small intestine. This has the effect of reducing the rapid spike in blood sugar levels that can occur after eating, providing a more gradual release of nutrients into the bloodstream.
Appetite Regulation: GLP-1 plays a role in appetite regulation by signaling to the brain that the body is full, which can lead to reduced food intake and contribute to weight management.
Due to its effects on insulin secretion, blood sugar regulation, and appetite control, GLP-1 has become a target for medical interventions aimed at treating diabetes and obesity. Some medications, known as GLP-1 receptor agonists, have been developed to mimic the effects of GLP-1 in the body. These medications are used to help control blood sugar levels in people with type 2 diabetes and can also lead to weight loss in some individuals.
It’s important to note that while GLP-1 therapies have shown promising results, they should be used under medical supervision, as they can have various effects on the body and may not be suitable for everyone. Always consult a healthcare professional for advice on managing your health conditions.
If your BMI falls below 27 while you are on GLP-1 medication, it’s important to have a conversation with your healthcare provider. GLP-1 medications are primarily prescribed for individuals with a BMI of 27 or higher, along with obesity-related health conditions, or for those with a BMI of 30 or higher without specific health conditions. If your BMI falls below these thresholds, your healthcare provider may need to reevaluate your treatment plan and consider whether continued use of the GLP-1 medication is appropriate.
Here are a few things that might happen or be considered in this scenario:
Medication Adjustment: Depending on the specifics of your situation, your healthcare provider might decide to adjust your medication regimen. This could involve reducing the dosage or discontinuing the GLP-1 medication, especially if your weight and health status no longer meet the criteria for its use.
Lifestyle Assessment: Your healthcare provider may review your current lifestyle habits, including diet and physical activity, to determine whether these factors are contributing to the decrease in BMI. It’s important to maintain a balanced and healthy lifestyle even if you’re no longer taking the medication.
Follow-Up Plan: Your healthcare provider might schedule regular follow-up appointments to monitor your weight, health status, and any changes in your condition. This will help ensure that you’re maintaining a healthy weight and that your overall health is being properly managed.
Transition to Maintenance: If your BMI falls below the recommended threshold and your health is stable, your healthcare provider may help you transition from a weight loss-focused plan to a weight maintenance plan. This could involve adjusting your diet, exercise routine, and overall approach to maintain a healthy weight.
Continued Support: Regardless of whether you continue with the GLP-1 medication or not, your healthcare provider can offer ongoing support and guidance to help you maintain a healthy weight and manage any underlying health conditions.
It’s crucial to communicate openly with your healthcare provider about any changes in your weight, health status, or medication response. They can provide personalized advice and recommendations based on your individual circumstances and help you make informed decisions about your treatment plan.
The amount of weight that can be lost with GLP-1 medication can vary widely depending on individual factors such as baseline weight, adherence to medication and lifestyle changes, underlying health conditions, and genetic factors. Clinical studies have shown that GLP-1 receptor agonists can lead to significant weight loss, but the exact amount can differ from person to person.
On average, individuals using GLP-1 receptor agonists for weight loss can expect to lose anywhere from 5% to 15% of their initial body weight over several months to a year. This range is based on clinical trial data and real-world experiences. Some people may achieve weight loss beyond this range, while others may experience more modest results.
It’s important to note that the effectiveness of GLP-1 medication is often enhanced when it’s used as part of a comprehensive weight management plan. This plan typically includes a combination of medication, dietary changes, increased physical activity, and behavioral modifications. The medication can help reduce appetite and promote feelings of fullness, making it easier for individuals to make healthier food choices and control portion sizes.
However, it’s essential to have realistic expectations and remember that weight loss results can vary. Not everyone will experience the same degree of weight loss, and individual responses to medications can differ. Additionally, weight loss achieved with GLP-1 medication can be sustainable as long as healthy lifestyle habits are maintained even after discontinuing the medication.Before considering GLP-1 medication for weight loss, it’s important to consult with a healthcare provider who can assess your individual situation, guide whether this type of medication is appropriate for you, and help you develop a personalized weight management plan.
Eligibility for weight loss medication is determined by several factors and should be evaluated on an individual basis by a healthcare provider. Weight loss medications are typically considered as part of a comprehensive approach to managing obesity and overweight, and they are usually recommended when lifestyle changes (such as diet and exercise) alone have not been effective or when there are significant health risks associated with excess weight.
It’s important to note that weight loss medications are not suitable for everyone. They come with potential side effects and risks, and their effectiveness varies from person to person. Before considering weight loss medication, consult with a healthcare provider who can assess your individual situation, guide the most appropriate options, and help you develop a personalized weight management plan.
GLP-1 prescription weight loss medications can be beneficial for certain individuals in managing weight loss and metabolic health. However, there are specific groups of people who should not take these medications due to potential risks or contraindications. It’s essential to consult a healthcare provider before starting any new medication, including GLP-1. Here are some groups of individuals who might not be suitable candidates for GLP-1 prescription weight loss medications:
Pregnant and Breastfeeding Women: The safety of GLP-1 receptor agonists during pregnancy and breastfeeding is not well established. Pregnant or breastfeeding women should generally avoid using these medications unless advised otherwise by a healthcare provider.
History of Medullary Thyroid Carcinoma (MTC) or Multiple Endocrine Neoplasia Syndrome Type 2 (MEN2): Some GLP-1 receptor agonists have been associated with an increased risk of thyroid C-cell tumors in animal studies. Individuals with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN2) should generally avoid these medications.
Severe Gastrointestinal Disorders: GLP-1 receptor agonists can cause gastrointestinal side effects such as nausea, vomiting, and diarrhea. Individuals with a history of severe gastrointestinal disorders might be more prone to these side effects and should use these medications with caution.
Type 1 Diabetes: GLP-1 receptor agonists are primarily used for individuals with type 2 diabetes or for weight management. They are not typically prescribed for people with type 1 diabetes, as their mechanism of action is more closely related to insulin production and glucose regulation in type 2 diabetes.
History of Pancreatitis: Individuals with a history of pancreatitis (inflammation of the pancreas) should use GLP-1 receptor agonists with caution, as these medications can potentially increase the risk of pancreatitis.
Renal Impairment: Some GLP-1 receptor agonists require dose adjustments for individuals with moderate to severe renal impairment. Your healthcare provider will need to assess your kidney function before prescribing these medications.
Severe Liver Impairment: Individuals with severe liver impairment may need dose adjustments or should avoid GLP-1 receptor agonists, as these medications can affect liver function.
Allergies or Sensitivities: People who have known allergies or sensitivities to GLP-1 receptor agonists or any of their components should not use these medications.
It’s crucial to have a thorough discussion with your healthcare provider about your medical history, current health status, and any potential risks or contraindications before starting GLP-1 prescription weight loss medications or any new medication. Your healthcare provider will assess your situation to determine if these medications are appropriate for you.
Age restrictions for GLP-1 medication and visits can vary based on several factors, including the specific medication, the healthcare provider’s discretion, and the patient’s individual health circumstances. GLP-1 medications are primarily used to manage type 2 diabetes and support weight loss in adults, but some medications might have different age indications. Here are some general considerations:
GLP-1 Medication Age Restrictions:
Most GLP-1 medications are approved for use in adults, typically those who are 18 years of age and older. The age restrictions might vary depending on the specific medication and the country’s regulatory guidelines. It’s important to note that these medications are not typically used for children or adolescents unless under exceptional circumstances and with close medical supervision.
Healthcare Provider Visits:
Visits to healthcare providers for the purpose of discussing GLP-1 medications, weight management, and metabolic health are generally open to adults. If a younger individual has specific health concerns, such as obesity or type 2 diabetes, healthcare providers may see them for evaluation and guidance.
In cases involving individuals who are younger than 18 and have concerns related to weight management or metabolic health, a healthcare provider specializing in pediatrics or adolescent medicine might be involved. Pediatric endocrinologists and other specialists can offer appropriate guidance and recommendations tailored to the individual’s age and developmental stage.
It’s important to emphasize that medication use, especially for weight loss and metabolic conditions, should always be overseen by a qualified healthcare provider. If you or someone you know is seeking medical advice or treatment, it’s best to consult with a healthcare professional who can provide personalized guidance based on individual health status, age, and medical history.
A dual GIP/GLP-1 receptor is a target that responds to two different hormones, namely GIP (Glucose-Dependent Insulinotropic Peptide) and GLP-1 (Glucagon-Like Peptide-1). Both hormones play roles in regulating blood sugar levels.
The receptor responds to both GIP and GLP-1, influencing insulin secretion and glucose regulation. Activation of this receptor is designed to improve blood sugar control in individuals with conditions like type 2 diabetes.
Targeting both GIP and GLP-1 aims to provide a more comprehensive approach to managing blood sugar levels. GIP and GLP-1 have complementary effects on insulin release and glucose metabolism.
Side effects can vary depending on the specific medication. Common side effects may include nausea, vomiting, or gastrointestinal issues. It’s crucial to discuss potential side effects with a healthcare provider.
Whether you’re overweight or in maintenance, we believe obesity is a lifelong condition that can be managed. If, during your consultation, you and your Brello provider determine you’re not a suitable candidate, we’ll cancel your membership and provide a refund.
Certainly! Just notify us if you wish to cancel, and your plan will be terminated at the end of the current term with no cancellation fees.
Our service coverage is continually evolving. For the most current information on the states we serve, please view our licensed states here.
Our providers prescribe semaglutide and tirzepatide based on their clinical data, safety, and effectiveness. We strongly believe these once-weekly injections represent the best available options.
Yes, Brello is pharmacist owned and operated. Our pharmacy, Southend Pharmacy, conducts quality tests on each medication batch for potency, sterility, and dosage.
Your prescriptions are sent directly to Southend Pharmacy to be processed and shipped within 5-7 days.
We do not currently accept medical insurance for any of our services. However, you will receive invoices that you can submit to your insurance company for potential reimbursement.
Uncover a weight loss strategy that addresses the core of the challenge – your unique biology. With Brello, we turn your biological blueprint into your biggest ally in the quest for sustainable weight loss.
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